We have PII, analytics, catalog, transaction etc databases. We only let people clone non-sensitive databases. Others are cloned only at schema level and data is left out.

This also allows us to move and scale independently across different applications. But that's just a symptom of this design.

There are some complications with this approach but it's a trade off and we try to come on top using foreign-data-wrapper approach and using a database application router for read and writes. We have open sourced a Django db router which routes queries on the basis of tags/app name/table name etc