I find that as we gain new tools to study the nervous system more specifically, both data and models of how neurons are organized at the circuit level become more important. To advance on an analogy in the article, it's like trying to explore the dynamics of NYC without a map. For instance, it's hard to tell how/why people interact with central park if you don't even know where they live. The more specifically you are able to pin down people, the more it matters where exactly they live to understand.
Granted, the fly is much simpler than humans or even mice, and it will likely take decades and new tools for us to study humans in this way. However, when we get there, mapping out the brain connections will be crucial to make sense of it all.
This made me realize we may one day willing allow human brain controls to get us to do things we don't want - Work, Exercise, etc.
We already have that: coffee.
Similar tricks can be played with the human brain, things we have been able to do for decades, while people are undergoing brain surgery, and now later, with TMS. However, being able to elicit limb movements or bits of speech, or even emotional qualia is different from having a dynamic understanding of the brain in vivo in everyday life.
Certainly having an understanding of detailed circuitry is interesting and important, but to me there's a forest for the trees problem.
I really hope we can realize how the whole thing works by looking at its parts. But I doubt it will bring the breakthrough. On the other hand maybe there is this one mechanism that we have to discover to make sense of all the parts. Then those efforts will form the groundwork for an explosive understanding.
My impression is that there's a lot of very oversimplified assumptions being made all the time in these fields that get glossed over in very arrogant (or naive?) ways. It's really astonishing to me, not just because of how oversimplified the assumptions are but because researchers are then surprised things don't work out.
To be fair, this is true of other fields as well. I'm more familiar with molecular genetics and genomics, and the same things happen there. There seems to be a certain hubris that goes unquestioned, and it always amazes me, the sci-fi fantasy narrative being accepted as fact.
Just to take one thing for example: there's huge anatomical differences between people's brains even at the macroscopic level, that just get glossed over in discussion. Those fMRI images you see? They're often done by aligning different images to a common map, just assuming individuals' brains are carbon copies of one another. Now you're going to try to delineate a connectome at the neural level, as if there is one connectome at that level?
When will everyone learn? Where's the public skepticism?