For example, when a mathematician starts reading a paper that uses too many acronyms, they generally freak out. It's a strong signal that they've wandered into the wrong part of town. While there is brilliant work done in applied domains, one rarely finds it in acronym-heavy papers.
After a lifetime of reinforcement with this filter in place, it's very hard to read FOCUS as anything but an acronym. That's not what you intend, so look into styling your html with bold or italic emphasis?
(I was at a faculty meeting that was spending an unreasonable amount of time debating an acronym for our salary committee, something that would reinforce the message that there are other aspects of our compensation. My contribution: "I love how Brits use short words for things. As a member of the most symbolic department, I'd like to speak in favor of an acronym-free workplace." I got the Provost evil eye.)