Why can't those be moved to space?
But those are a special case, air cherenkov telescopes are looking for "less weird" particles like photons or protons. Those can only be seen looking up, since the primary particles moving down focuses the cherenkov light down in a narrow cone.
Basically a big bubble filled with the most useful gas for this + bunch of photodetectors inside at the appropriate places. You could also make the whole detection chamber much larger, than the ~30 km (?) of reasonably thick atmosphere you get on Earth.