> One of Watson’s obsessions has been to “improve” the “imperfect human” via human germline engineering. This is disturbing on many many levels. First, there is the fact that for years Watson presided over Cold Spring Harbor Laboratory which actually has a history as a center for eugenics. Then there are the numerous disparaging remarks by Watson about everyone who is not exactly like him, leaving little doubt about who he imagines the “perfect human” to be. But leaving aside creepy feelings… could he be right? Is the “perfect human” an American from Chicago of mixed Scottish/Irish ancestry? Should we look forward to a world filled with Watsons?
Then he brings up the topic of "good" and "bad" SNPs and seques into an inane argument about ethnicity of perfect human: «since many disease SNPs are population specific», "admixed" Puerto Ricans are superior. But that's working backwards from the conclusion, not a knockdown argument against Watson's dream. To wit: Watson is racist and racists are obviously wrong, therefore we should renounce research into human germline engineering. Most damningly, Pachter poisons the well of engineering by tying it to eugenics with nothing but guilt by association.
Now, any non-indoctrinated human can understand that the issue of "perfect" phenotype is not about modern groups at all; indeed, every human on the planet has a decidedly wretched genome. A word to Maynard Olson, one of the founders of the Human Genome Project:
> So, what have our first glimpses of variation in the genomes of generally healthy people taught us?... What is on the top tier? Increasingly, the answer appears to be mutations that are “deleterious” by biochemical or standard evolutionary criteria. These mutations, as has long been appreciated, overwhelmingly make up the most abundant form of nonneutral variation in all genomes. A model for human genetic individuality is emerging in which there actually is a “wild-type” human genome—one in which most genes exist in an evolutionarily optimized form. There just are no “wild-type” humans: We each fall short of this Platonic ideal in our own distinctive ways.[1]
It seems that Watson was correct again.
The degree to which we fall short, to which we are damaged by deleterious mutations, is hard to appreciate, but near-certainly astronomical. By helping to suppress this line of research with his non sequitur and vitriol, Pachter subjects future generations to an avoidable misery of historically known human condition. Gwern makes a compelling case for intelligence: «since existing differences in intelligence are driven so much by the effects of thousands of variants, the CLT/standard deviation of a binomial/gamma distribution implies that those differences represent a net difference of only a few extra variants, as almost everyone has, say, 4990 or 5001 or 4970 or 5020 good variants and no one has extremes like 9000 or 3000 variants—even a von Neumann only had slightly better genes than everyone else, probably no more than a few hundred. Hence, anyone who does get thousands of extra good variants will be many SDs beyond what we currently see. »[2]
But since so much is heavily hereditary, the same logic is true for longevity, willpower, general health, mental health, hedonic tone, beauty of course... Our descendants could be as Gods, way above ugly squabbles for ethnicity rankings that we have and Pachter is obsessed with – but only if some Professors of Computational Biology don't succeed at completely brainwashing people on fairly uncontroversial topic.
Article Pachter links to is also just opinionated blather and guilt by association:
> Watson then sought to pre-empt any scientific self-doubt: “We should be proud of what we’re doing and not worry about destroying the genetic patrimony of the world, which is awfully cruel to too many people,” he said. “We get a lot of pleasure from helping other people. That’s what we’re trying to do.” ... Making “better human beings” differs from making human beings better by curing their diseases. Making better human beings is more closely aligned with the old eugenics vision. The previous century’s eugenicists sought to breed better humans by promoting specific types.
Besides the heavy–handed implicit demand to clutch pearls at Watson's suggestion, I don't see how he is wrong or bad, and how the author is making an argument at all.
A community of hackers should be able to easily understand the eldritch horror or a long, highly redundant, 90% dysfunctional code that evolved by random alterations and no fitness function sans "can actually survive" running their entire biochemistry; as well as the potential for improvement here. But no, listening to politically motivated demagogues is more fun I guess.
It's a shame really.
1: https://science.sciencemag.org/content/331/6019/872.3 2: https://www.gwern.net/Embryo-selection#limits-to-iterated-se...