Your point 2 is very important and what so often gets missed. What is statistically significant may not be clinically significant; throw enough patients at something, especially a surrogate outcome, and you can get p<0.05. The hype hungry media then pick that up based on a press release as a wonderous new treatment for disease X.

The reality is most things are incremental improvements, but few diseases are truely curable. Most cancer drugs we have extend survival (by impressive amounts), or in other conditions manage symptoms. Fundamentally however you will probably still die of the cancer, and will still have the condition, just with an extended course. This is huge, and almost magic... but it isn't the miracle cures people want to share on social media.