So your target audience is strictly (US) English?
So your target audience is strictly (US) English?
Of course, it is (almost) impossible to account for the enormous amount of keyboard layouts that exist, so I wish we could agree to use key positions over the characters they produce for shortcuts, so we can cover a significant portion of the population with ANSI/ISO layouts. I'm honestly not sure what keyboard layouts are used in countries with entirely different scripts, but my cursory Google searches suggest the physical layout is the same as ours.
Sure, you might lose some mnemonics on layouts that aren't QWERTY, but at least the majority of shortcuts would be usable by default compared to having to remap them in every application. The application could even resolve what keys are actually mapped to the physical keys and display the correct shortcut in menus.
Destiny 2 actually seems to do this and does, as far as I was able to tell, an excellent job of it.