Do not rely on a single drive or you'll end up in a situation like me where one day your external drive decides to stop working and 20gb of photos are gone.
While I do keep a single drive backup, to restore my entire drive from, but I do not test this backup. If it doesn't work, it's not that big of a deal. I cherry pick what I really find important and burn it to M-DISCs. Very little content is actually that important, baby photos and things like this.