A note here: when it comes to discovery, motivation is vastly more important than competence and every disciplined effort will lead to greater understanding or a serendipitous result of some kind.
On the other hand, nobody can know the probability that he'll solve a problem.
Yet important problems can be reliably identified. What I'm trying to point out is that there's nothing wrong with going after the big ones.
>But I’m hopeful this log-jam will be temporary, and that new opportunities are opening up for aspiring scientists.
To put this in context he has also stated he thinks that civilisation has only a 50% chance of surviving this century. Another reason for tackling big problems IMO.