How do you recommend running it? The install guide lists a half-dozen different possibilities including PHP, Node, Ruby which all look to be vastly different solutions.
Other options do things like public hosting.
Personally, I just use the HTML file with the Timimi Firefox plugin installed for autosaving the current file.
> Don't attempt to use the browser File/Save menu option to save changes (it doesn't work)
It looks like TiddlyWiki doesn't recommend that exact method anymore.
You "Save As.." that.
To save changes, click the red checkmark, and "save as..." the updated HTML over the old copy.
Switch to other possibilities if you use it enough to justify that.