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I switched to mutt after finding myself in the same boat with most GUI clients. After writing a few save-hooks and macros (the hard part), I can check and process all of my accounts in a minute or two, even on a slow connection (great for vacations). Since I version control my ~/.mutt directory, it's easy to deploy on multiple machines. If I don't have access to mutt, my phone or webmail serves as an adequate backup.

Sparrow does labels, clean views and has Gmail keyboard shortcuts (if you enable them) and is super fast. Been a beta user for months now...

Yeah, I tested Sparrow a while back - shame it's no longer possible to try it out. :(

Give it a couple of days. The Free, but ad-supported, version is still under Review

sup (http://sup.rubyforge.org/) is like gmail for the command-line. It's a beautiful thing.

And if you don't want to be entirely locked in to sup, http://notmuchmail.org/ is also a great option

There were a few OSS efforts to develop a new browser, one lead by Brent Simmons, but they all imploded.