GURPS for me is the quintessential cyberpunk role playing experience. Its gritty realism suits the genre way better, in my opinion, than systems like Cyberpunk 2020. The bionics / cybernetics systems and point based character creation really opens things up for creating the kind of character you want versus being stuck in an archetype that the genre defines. GURPS is an amazing toolbox for simulating a lot of gritty and deadly combat. A lot of people don't like that you can calculate what you need to roll in order to shoot a person in their left eye as you drive past at night on your motorcycle and prefer a more abstract system. In that case, I'd move towards the Apocalypse World system. It's a much more modern role playing experience without a lot of the issues that GURPS or D&D style games face.