You can make some really nice looking games using isometric tiles, Ceasar 3 comes to mind. Which looks much better then Ceasar 4 IMHO, which is 3d AFAIK. And game-play also feels better in C3.
I've tried a lot of the newer city builders and the 3D just does not do it for me. I find it clunky and awkward.
Also: plebs are needed.