CS50 is good, but I personally don't like it. I prefer MIT/Princeton/UCB intro courses comparatively. CS50 starts off with C for 3-4 weeks IIRC. Then moves on to python/sql/webdev. Not only is this fast paced, but it also covers a lot of breadth in a short time. For a self learner who has a full time job without proper support structure like peers and office hours which you get in the on campus version, it is difficult (not impossible) to go with the pace of the course. I do agree Malan is a great instructor.

In contrast, I like the MIT/Princeton/UCB courses since they use an easier language to start with and also introduce C in the later courses for systems programming.