Aspera: a high-performance data transfer suit, used in genetics and the film industry. I wrote a blog post about it a year ago and still get near-daily emails asking me if there is an open source alternative yet. QUIC may provide a basis for a solution, but it needs to be explored.
PDMS: software for planning, modeling and simulating oil and gas plants. Main two commercial suites are AVEVA PDMS and Autocad Plant 3D. AVEVA PDMBS is upwards of $1,000 per seat per month (!), so not feasible for projects which I have in mind (more on that in the new year). I'd imagine that Blender could be used as a starting point for a Free alternative, but I'm not sure. This is a tougher one.
[1] https://www.ccdatalab.org/blog/a-desperate-plea-for-a-free-s...