One mental model that helps reduce this load, that you alluded to, is avoiding product types where possible in favor of sum types.
Eg. Imaging you have a type describing React props for some component: {a?: number} and {a: number} | {} seem very similar on the surface — they both describe an object with a single field that may or may not be defined. In both cases you have 2 possible states.
But as soon as you add another field, the number of states can grow quickly unless you’re thoughtful: {a?: number, b?: string} has 4 states, while the model you might have been trying to describe — {a: number} | {b: string} — still has just two.
The less states you have, the easier it is to reason about and automatically verify your model. But in practice, people often accidentally introduce product type where they meant to use sums. I see this with Flow and TypeScript-typed React code all the time.