Depends what you are doing. Docker is just containers so shares the host kernel, and isn't quite as secure as a VM. This actually spins up guest VMs running their own kernel, isolated via hypervisor.

If you are running anything that requires kernel changes, containers won't really work (there are ways around it but I feel it's hacky. I could be convinced however). If you're running potentially evil software, VM is also much more the way to go.

multipass is virtualization (KVM, Hyper-V, etc) and not containers.

This runs on Mac and Windows, where you cannot run lxc containers (although I understand now that Docker supports some sort of native Windows containerization).