Scrolling, click to view replies, click to reply, click to retweet, click to like, click to view hashtag feed, click to view persons profile.
All of these things could be done efficiently with the keyboard (theres also no real reason to not still support mouse for the people who prefer it). I use the online checklist tool Checkvist.com and checklists are surprisingly similar to a linear feed like twitter. I use it almost exclusively with the keyboard, including editing, reordering, creating new items, tagging, colouring... Its super efficient and comfortable. There is no reason why you couldn’t have similar navigation and interactions on twitter. Personally, I find your outright dismissiveness of a keyboard-centric UI for twitter to be laughable shrug
Besides, you can create a keyboard centric UI without removing mouse support if you really want. It’s just that keyboard should be treated as a first class interaction method, instead of an almost tacked on accessibility feature.