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There is an even easier way. Use nginx.

Agreed, nginx is nice (I'm using it to serve static content on my blog in front of Apache). But nginx requires additional setup with WordPress to get it working properly, in particular mod_rewrite rules (especially if you then use WP Super Cache, or at least that's what it was like on Lighttpd when I used to use that).

I don't consider WordPress to be server agnostic - it's built for Apache and it only works well on IIS because Microsoft made some effort to make it happen.

Agree. I had to optimize my wordpress installation recently including some caching. Since there is not that much information about nginx, I took some notes and wrote about it. Here is my blog post:

http://blog.rassemblr.com/2011/01/wordpress-need-for-speed-o...

Nice resource, I'll update my post with a link to that.

There's also this post from patio11 that, amongst other things, describes what he does to use nginx + wordpress.

http://www.kalzumeus.com/2009/08/22/using-wordpress-and-rail...

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