I used to develop and sell novel earnings forecasts which would outperform analyst consensus. Typically my research would have a <1% margin of error on forecasting a specific KPI directly relevant to corporate revenue and profit for an equity. The best hedge funds were able to successfully trade on this information because they combined it with a significant amount of complementary data.
But I would not want to develop a trading strategy based on that data alone. These guys did very well considering the information they had to work with and how primitive trading earnings is. The real money in insider trading is in more illiquid OTC markets, or in mergers/acquisitions.
[1]: http://chloexie.com/pdf/ChloeXie_JMP.pdf
[2]: https://www.bloomberg.com/opinion/articles/2019-11-26/knowin...
This one's easy. Buy shares of the acquisition, wait for a 10%-50% pop on the news.
Trading on earnings is hard. Even if you check earnings against estimates, did they beat the street? How's the forward guidance look? And you only get four shots per year.