The first is that keyboard input is much easier to reliably repeat. Keyboard macros are much less simple with a mouse and even when keyboard macros aren't an option, I often find it easier when making repetitive inputs to convert the inputs to key presses and repeat them.
Furthermore, I find mouse usage interrupts my flow. Using the mouse is a very different mode of input than keyboarding. I have the disadvantage that my dexterity is worse than many people's and so when I have to switch to the mouse, I have to be very careful to click the right thing. I don't usually make the same mistakes with keyboard shortcuts that I use regularly. Even if the mouse is technically faster, that interruption is very unpleasant.