Antarctica? Check. Mysterious underground lake? Check. Driven scientists? Check. Extremely isolated location? Check.
Here's how I see it going down:
Drill pierces lake; eldritch horror escapes or is otherwise unleashed as consequence of scientific hubris; Vostok station's radio transmissions cease suddenly; a team is sent to investigate... maybe they find the sole survivor of the original drill crew (he's gone horribly insane, of course), eking out an existence in what remains of the research station... he warns the investigators not to go down to the drill site...