For me, I notice the difference in my shoulders. They tuck in with a compact keyboard, and then my wrists bow inward. It ends in a slouch and increasing neck pain over time - even my personal laptop makes this noticeable after a short amount of time.

Ergodox EZ may puzzle people with its layout, but the split island part alone has made computing comfortable for me, especially when combined with a sit/stand desk. There's a lot less physical strain to wrestle with, which a bigger difference as time goes on.