I have no sympathy. As far as I'm concerned, all automated email is spam. If it didn't come from a person you care about, it isn't worth your time.
Transactional, mailing list subscriptions?
When I buy shit, it shows up in my bank statement. I don't need or want an email from you.
Nor do I give a shit about your mailing list unless it's one in which I can participate by posting replies. Broadcast mailing lists can fuck right off: RSS or GTFO.
It's for a direct audience like we don't spam with unuseful or annoying stuff, they actually want real updates lol.