Let me shed some light into this:
Chrome 80 will most likely get released in January, since Chrome Canary already no longer needs the flag.
You can run the dist/development and dist/production versions of neo inside FF & Safari right now, the performance should be close.
Having 1 browser which fully supports it is enough for a great debugging experience. Obviously it would be nice if other browsers do catch up.
Mobile: I need to add support for touch events inside the main thread, which should be easy. On my todo list after the real world 2 app is done (want to focus on this one first, since it is meant to be a good starting point for new devs to get up to speed). The multithreading performance will be amazing on mobile.