Much faster, as it is UDP-based, it basically just keeps spraying network packets. I noticed that my SSH sessions are resumed after closing and reopening my laptop half an hour later.
In terms of speed, they are comparable. The great benefit of WireGuard is simplicity on Linux compared to the configuration nightmare that is StrongSWAN, but implementing IPsec/IKEv2 on OpenBSD using OpenIKEd is roughly comparable if you use Let's Encrypt certificates.
You can get really inexpensive GL.inet GL-MT300N-V2 "mango" boxes (about $20) that will provide transparent WireGuard or OpenVPN encryption for a device that doesn't support VPNs out of the box (ahem, a Smart TV or streaming box, to bypass geo restrictions). They don't support IPsec.
Can run. OpenVPN is UDP 1194 by default.
TCP-over-TCP is a well known tricky problem, so it's not something you want to run unless you have to.