For authors or books I'm unsure of, or just trashy stuff, I'll buy Kindle.
For technical books, I'll usually try to buy non-DRM PDF or eBook from the author, or failing that, a paperback.
I periodically (like, once a year or so) try to strip the DRM from my Kindle collection and back it up, but I basically assume that they could disappear at any time, so I don't trust them for anything I consider important.
I used to use an iPad2 for reading my Kindle books, but it's too slow to open the collection now (since I have a few hundred Kindle books). I'll likely get a Kindle reader of some sort one day, but for now I just read them on my phone most of the time.