Humanity is periodically faced with the fact that it is not special [0] and that it lives on an insignificant little blue planet [1]. I don't see that trend changing anytime soon.
What comes to mind of course is Artificial General Intelligence, or AGI. Although I only believe in eventual AGI many years from now, I think it's very interesting to foresee the potential impacts of a machine sitting on the step above in that ladder. See Nick Bostrom's Superintelligence [2], a great read.
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[0]: https://tvtropes.org/pmwiki/pmwiki.php/Main/HumansAreSpecial
[1]: https://tvtropes.org/pmwiki/pmwiki.php/Main/InsignificantLit...
[2]: https://www.goodreads.com/book/show/20527133-superintelligen...