We invented farming and lost our communal hunter gathering cultures. We invented mass production and supply-chains for our food and lost our farming culture (for the most part). This isn't necessarily good or bad, but we are definitely losing something every time we invent something to make our lives easier. At some point there will be a tipping point of diminishing returns.
Personally I believe "the singularity" would be the worst possible thing to ever happen to humans. Sure we can visit distant parts of the universe and live forever but only as passengers to some AI. Would you rather be a dog in today's world or a human 1000 years ago?
Progress is unrelenting though and I certainly enjoy not having to wash my clothes by hand.