My arguments are not on the familiarity side (with the infix notation), but on the psychological one:
1. S-expressions are not the most simple, natural, or uniform surface form (as they claim); they do have syntactic sugar (quote, even lists themselves!, etc.), so why not to add some more sugar (but sufficiently abstract of course)?
2. Humans' brain has limited "stack" space (especially when closing parentheses); infix forms may "cascade" and do not consume the stack (equally machine on human, due to possibility of "tail recursion")
3. Lack of diverse "visual clues" for humans (note how most natural languages have 40-60 phonemes, and none less than 15)
4. S-expressions and homoiconicity are related but orthogonal features (so the homoiconicity argument is often not valid)
Having that said, when I finally managed to write a working 50+-lines program in Scheme, with "proper" indentation, I was just proud of it, and I said, "Wow, it looks cool!". But I am still on the side of the above rational arguments! My point is that as my experiment demonstrates, it is probably too easy to get on an emotional side of computer-human interaction once you accomplished something a bit challenging (like speaking in classic S-expressions)?