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Mailinabox is a fully configured service. You need a fresh ubuntu install, you run the install script and it configures everything for you and notifies you when it needs to be updated or something is not as it should be.

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So it handles firewall rules, disabling root login and all those details?

Yes. And comes with a neat status page to warn you of any issues in case things change (but they shouldn't if you use a dedicated box).

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