You could invoke pipes from any webpage without worrying about cross-domain access.
If you look at some janky JS code[1] I had on my website at the time, you can see what you can do with it.
That would basically source
://pipes.yahoo.com/pipes/pipe.run?_id=7CTRtbtL3BGX_AHbjknRlg&_render=json&_callback=load_daily_show
as a static asset in my page, which would load the JS and call load_daily_show(<json>) as a result.
Now, EVERYONE who hits my page is invoking the pipe as a backend API call, with no caching and unfortunately with the entire Y/T cookies intact.
[1] - https://web.archive.org/web/20081007043923/http://t3.dotgnu....