Try getting hired after being out for 12 or more months after having a heart attack, or cancer, or whatever. Even if you're medically cleared. From personal experience, it can be difficult regardless of reputation.
Edit: And yes, I also tried the whole "took some time off to be with my family" thing as well, and that turned potential employers off even more (had one tell me, "we're not really interested in hiring people who aren't driven to work every single workday" regarding my "time off"). Happily, I did find a good company several years ago that pays well and offers a great environment, but it took significantly longer than I had hoped.