I've been "joking" with my friends that I want to take a trip to Costa Rica to do Ayahuasca with them.
The "story" of how Ayahuasca came to be is quite fascinating: Ayahuasca, the drink, is actually comprised of two plant-based ingredients. One of the ingredients supplies the "DMT" portion, but the effects would last a very short time (something like 20 seconds to a couple minutes. My numbers might be off).
Then they stumbled on this second ingredient, which grows in a completely different area of the jungle, which prolongs the effects of the first ingredient (I'm guessing this is the MAOI portion, but I'm not 100% sure). Combining these two ingredients into the "Ayahuasca" we know today, the experience went from short 30-second trips to these 6-12 hour "sessions".
The most interesting part is that the shamans claim it was the "plants" or the "plant spirits" that told them to seek out the second ingredient and combine the two.