Can anyone explain in layman terms what this means? Does it mean that supercentenarians' immune system posses a unique ability to kill cells?
Having more cytotoxic CD4 T's could give the immune system better ability to destroy invaders or cancer cells.
Even more surprising is that a large percentage of these mutant CD4 T's are clonal, all traceable back to one individual (T cell) that mutated.
It's been shown that supercentenarians enjoy resistance to disease over their entire lives. This research shows that may be due to their unique immune systems.