Yes. I haven't found over the ear gaming headphones that I can wear. I've tried countless sets, and all result in a headache after about 30 minutes. My preferred gaming headset is a behind the neck style.

I think the headaches (for me) result from pressure (clamping force), not necessarily the noise-cancelling. The Sony's and the Bose were both light enough that there isn't much of a clamping force from left to right on my head. I do not get a headache from the Sony's and did not from the Bose either.

Some people feel headache due to Noise canceling. There are lots of reports about it.

I never felt anything.