I mean, in theory the web is a cesspool of malware, but with reasonably good content blocking (I’m not even in the completely-disable-JS crowd) and conscious avoidance of shady sites, I managed to pretty easily stay clear of all attacks so far, at least over the past decade.
Those way more paranoid than me still have the option of using local VMs/containers without too much compromise. Then the attacker really needs an exceptional exploit chain to escape all the way; it’s hard to imagine any group blowing such a valuable chain on a drive-by.
So, why would anyone sacrifice the ability to interact with text, resolution, color accuracy, frame rate, etc. to reduce the minuscule chance of drive-by attacks (assuming otherwise reasonable opsec)? Extremely high value targets?
But then, why would extremely high value targets trust a MITM? (Self-hosting apparently changes that to some extent.) Also, even if you run your browser in the cloud, that browser could still be hacked and leak sensitive information or actively modify traffic, no? So this isn’t even bulletproof for high value targets.