With the first problem, they can simplify things considerably by paying an ARM tax. The RISC-V tax is less ($0) but then it offers them less as well. If they design their own ISA, well, good luck with that. Also, clouds like tweaks, so one size won't fit all.
With the second problem, there's fab space to be had for sufficient coin. But there's more to manufacturing than filling out a webform and sending a tape with a check.
If they can get past the first two hurdles and actually deliver silicon which is significantly better than Intel's then marketing to the big clouds should be the least problematic.
Gonna take some money and time. Gulati left Google in March.