The most important ingredient in research is time. Don't count out garage research.
There is no substitute for professionalism in research, no matter the venue. Hard work, best practices, collaboration, and expertise are all essential.
I am presently in a time of change in my own research career, and a garage laboratory underwritten by an industrial job is beginning to look quite tempting. There are a lot of advantages, but the onus is heavily on the researcher to choose research directions that are compatible with that environment.
Barbara McClintock did her most-famous work in a shed with a small adjoining cornfield. I'm happy to wager that there are major discoveries left in biology to be made with similar equipment. The key is being able to eat, sleep, support loved ones, be healthy, and be able to get some research done.