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I created a site that uses Google CSE to do just this. The link is: http://blacklist-search.appspot.com/

http://userscripts.org/scripts/show/33156 never mind I just went out and found a script for it...

why not just use the - function?

Create something like:

http://www.google.com/search?q=google+-google.com&ie=utf...

I suspect you could hack together a quick greasemonkey script to automatically inject your negative site list when the URL is generated

This only works for a small number of blacklisted domains.

Because Chrome still doesn't sync your "search engine" settings. So maintaining a massive customized search engine across the multiple computers I use would be a pain. If this was a native feature it would work so long as I logged in to Google. Of course, if they fix chrome I'll be happy too.