Why pipx vs just using pip?
This difference is important due to dependencies- if you have two different CLI tools you want to install but they have conflicting dependencies then pip is going to put at least one of them into an unusable state, while pipx will allow them to both coexist on the same system.
pipx, poetry, pipenv and co are still nice wrappers to have, I suppose. It just feel less useful now that most of my projects are dockerized.
That way 'pipx install foo' can download and install wheels rather than downloading source distributions and building/installing them...