I don't understand the need for the arbitrary "without running something like wine" distinction. Wine has gotten head and shoulders better in the past year or so. Between the gallium nine direct 3d state tracker which gives better performance in Linux than in windows for directx 9 games, (!!) dxvk giving directx 11 support, <edit> vkd3d adding directx 12 support,</edit> and Valve's seamless integration of wine in the Linux steam client, wine is just peachy.

If your objection to wine is philosophical as opposed to practical, why is dual booting into Windows an alternative?