Cool design (back the days I suppose) but the wasted space (well, volume) introduced by that design is off limits.
others like fuller's dymaxion home were explicit about why the odd shape was chosen: structural integrity in a natural disaster, maximize ratio of livable space to raw materials, economize the physical footprint, mix/max it so you can mass produce it cheaply and house the world.
The one major drawback I find in structures like these is that I miss right angles. They help me orient myself in a space. A spheroid may provide maximal volume for its surface area, but if your residents are going to be ill at ease for any reason, they'll never choose it for their home.