I realize that a lot of their philosophy runs counter to the already unconventional wisdom here, but so what.
I also realize that we may soon hit 37signals saturation (much like techcrunch saturation) here, but again, so what.
Many of us are in less than optimal situations (money, time, resources, collaborators, etc.), so this is some of the best advice you can get...
"How about you turn your perceived weakenesses into strengths. Embrace your constraints..."
Excellent!
My own example:
I am frustrated that I don't have enough time to spend writing my own code because I still have several consulting gigs. So, instead of asking, "How can I get more time in my week?" I ask, "How can I use what I learn from my clients to cut through the fog on my own software so that I don't need as much time?" That change in framing has really saved me a lot of time.
Sometimes you just gotta change your view by asking a different question. A 37signals post has once again helped me to think outside the quadralateral. Thanks, DHH.