Graffiti was a breakthrough in art. (1970's, we all know it existed somewhat in Pompeii)
I guess it's a area were there is an obvious change that's happened and it's good for that field and it doesn't need proving because it's obvious and didn't use the scientific method to bring about the change.
Urber showed it was possible for a company to break corrupt monopolies and break BS government regulations if consumers wanted your product enough. Is a current example I guess? Trump style politics is another. Meme fanaticism is a new field.
Else, finance is not STEM, blockchain is a break through and we are talking what we always talk about. Internet allows non-STEM to train and communicate blah blah blah....
You couldn't have discovered it as a fetish through scientific experimentation. It probably wasn't one until it was used to bypass japanese censorship laws which also accidentally conditioned the popular psyche to associate it with porn.
There are still a lot of ongoing breakthroughs of this kind in hentai. For example the genre of monster/anthropomorphic girls is currently exploding. I recently beat my meat to a world war 2 battleship in the shape of a girl.