To classify mutation as "artificial" or "natural" is a fool's errand. Nature makes mistakes all the time, just like us humans - the only difference is we don't have hundreds of millions of years to even ours out. In the current age this may still be a "but religion and ethics" argument. This is conjecture, alas it will be a "if your nation isn't doing this, it is obsolete" fact by no later than 2100.