This does not necessarily invalidate your wider points, but just FYI:

> It does not interop with JavaScript.

Hm, this depends on your definition of "interop". My JavaScript and TypeScript are languages that exchange information. The execution model ultimately involves JavaScript when I use tsc, but ultimately it also includes an interpreter. My user-space syntax doesn't care.

> There is no such thing as a TypeScript runtime engine.

Not being glib, just a heaps up: https://github.com/denoland/deno