Yes and no.
If it is reported by a recipient using the report button most email providers have then your email host gets a black mark in various databases. With repeat reports over time, more and more of thier legitimate customers stuff gets filtered.
That means your email host is incentivised to find and shut down spam accounts, ideally before they start sending mail. Register a bunch of accounts from one computer or from a proxy? Closed.
You could get around this with your own smtp server buuut... If you send a lot of reported emails your home isp will chuck you. They don't want thier ip block blacklisted. Your cloud smtp spam server will be pulled by amazon and they won't let someone who seems to be you create a new account.
So yes, you can send a few manually written emails and send them to a couple people at a time, but anything with wider reach will be shut down rapidly at various levels.
Meanwhile, you can script create thousands of twitter bot accounts with obvious bot names and... If they are looking for them, they aren't looking harder than they are being made to.
I guess this is a strong argument for federated Internet infrastructure. Everyone is incentivised to play nice because thier partners can cut them off.