There are significant differences between psychedelics and anti-depressants, both mechanically and when it involves long-term treatment planning and monetization.

Although research is quite limited due to regulatory constraints, John Hopkins has particularly interesting research on the subject (https://hopkinspsychedelic.org), with ongoing trials.

I think you're right about the shamanic ideal - at its current state, this doesn't seem to be the kind of treatment you can scale through the form of a pill.