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To those that say DNA seq; although the cost to perform the actual sequence has dropped, there are still a ton of overhead costs in acquiring and managing any genomic data. Context - product platform guy at biobank.

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I mean, I suppose that depends on how you're defining "overhead" cost? To sequence a human genome, you _need_ to purchase a ~$700 reagent kit from Illumina to plop into your HiSeq and a ~$300 library prep kit -- are these overhead? I wouldn't call them overhead, and this fixed-cost hasn't really changed for 5+ years.

Those two costs are what makeup the $1000/human genome stat, we don't factor in the human and consumables components

How much does it cost you to source that data? What kind of programs are in place to maintain compliance? Who runs the sequencers and performs QC?

I'd like to see how those kind of costs stack up against the $0.6K-WGS. Yes, I understand the difference between marginal COGS and opex.

My impression is that the cost of the actual sequencing has dropped so much that it is the overhead costs that now dominate.

Well indeed, the Wikipedia entry posted below https://en.wikipedia.org/wiki/Carlson_curve shows _total cost_ dropping down to a plateau at $1k since 2016.

OK my bad, it is actually cost per genome. Don't -1 :)

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